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Research Shock due to profound hypothermia and alcohol ingestion: report of two cases by R Raheja et al., published by the National Institute of Health (NIH), indicates that alcohol consumption significantly reduces body temperature, and in cases of severe hypothermia after acute alcohol ingestion, perfusion failure is associated with hypovolemia, bradycardia, and respiratory depression. Cardiovascular Complications: High levels of alcohol affect heart rate and blood pressure, potentially leading to arrhythmias or cardiac arrest

To prevent it, wait a full 10 seconds after injecting before removing the needle

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Am J Med Sci 336(1):5052

Their distinct mechanisms dictate their diverse research applications